Everolimus

Afinitor®


Uses


What is Everolimus for?

Everolimus is a medicine that has been used for treatment of certain types of cancer e.g. kidney cancer, breast cancer, neuroendocrine tumors.

How should I take or use Everolimus?

It is a tablet, to be taken by mouth once daily at the same time.
Take consistently with or without food and swallow whole with a glass of water.

What should I do if I forget to take or use Everolimus?

If you miss a dose of Everolimus, take it as soon as you remember if it is within 6 hours of the missed dose. However if more than 6 hours have past, skip the missed dose and go back to your usual dosing. Do not double the dose.


Precaution


What precautions should I take when taking or using Everolimus?

  • Inform your doctor or pharmacist if you:
    • Have any other medical conditions e.g. diabetes, high cholesterol, hepatitis B
    • Are taking any other long-term medicines or supplements
  • Effective birth control should be used during treatment and for at least 2 months after stopping treatment. Inform your doctor if you plan to get or suspect that you are pregnant.
  • Do not breastfeed. Inform your doctor if you intend to breastfeed while taking Everolimus.

What food or medication should I avoid when I take or use Everolimus?

  • Grapefruit or its juice
  • Starfruit
  • Seville oranges

Side Effects


What are some common side effects of Everolimus?

  • Nausea or vomiting
  • Mouth sores
  • Decreased appetite, taste changes
  • Slight indigestion or diarrhea
  • Mild to moderate headache
  • Rash, dry itchy skin, acne
    Protect yourself from sunlight by wearing protective clothing and using sunscreen.
  • Increased blood pressure, cholesterol or lipid levels and blood sugar levels
  • Body aches and tiredness
  • Swelling of the leg or feet
  • Increased risk of infection
    To minimize infection risk, take precaution when visiting crowded areas or being around sick people.

Inform your doctor if any of the following occurs:

  • Allergic reactions – rashes, facial swelling, breathing difficulty
  • Rapid heartbeat or chest pain
  • Signs of infection – fever or chills, cough, sore throat, pain or difficulty in urinating
  • Signs of bleeding – bruising, black tarry stools, blood in the urine
  • Unusual weakness, tiredness or light-headedness
  • Sudden onset or gradual worsening of cough and/or breathlessness
  • Wounds that heal slowly or do not heal well
  • Be cautious especially if you have a history of diabetes.


Handling


How should I store Everolimus?

  • Keep away from children
  • Keep in a cool, dry place, away from direct sunlight
  • Store at room temperature

How should I handle Everolimus safely?

Do not break or crush the tablet.


For more information


What should I do if I overdose?

If you overdose on this medicine, inform your doctor immediately.

Disclaimers

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System, and SingHealth), community pharmacies (Guardian, Unity, and Watsons), and the Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last Updated on October 2017



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