Cowden Syndrome

The common cancers in individuals with a faulty PTEN gene

• Breast Cancer
• Thyroid cancer
• Uterine cancer
• Kidney cancer
• Colon cancer
• Melanoma
  

Note: The cancers associated with a faulty PTEN gene and their risk estimates may change as more information is available.

Other non-cancer features associated with CS include:

• A large head size (macrocephaly)
• Benign tumours of the thyroid, breast and endometrium
• Bumps/growths on the skin (trichilemmomas) or in the mouth (papillomatosis)
• Polyps (growths) in the colon or intestines
• Autism
• Developmental delay
• Blood vessel malformations or haemangiomas (strawberry marks)
• Benign tumours (lipomas) commonly found on the upper back and shoulders