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Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Medium-Chain Acyl-CoA Dehydrogenase Deficiency - Symptoms

What are the symptoms of MCADD?

Most people with MCADD do not show any symptoms unless they are sick, vomiting or not eating well.

Symptoms or signs that may be seen during illness or times of fasting:

  • Lethargy – tired and sleepy
  • Hypoglycaemia (low blood sugar)
  • Vomiting
  • Shakiness
  • Irritability


Left untreated, this can progress to:

  • Heart problems
  • Enlarged liver (hepatomegaly)
  • Seizures
  • Breathing problems
  • Coma
  • Death


The health outcome for most individuals with MCADD is excellent. Growth, development and general health are expected to be normal if the diagnosis is made early and emergency treatment is given during periods of illness or poor feeding.



When should I bring my child to seek medical attention?

Seek medical attention if your child:

  • Is vomiting
  • Has diarrhoea
  • Has an infection
  • Has a fever
  • Is hard to wake up
  • Refuses to eat due to nausea or sore throat
  • Is scheduled for medical or dental procedures or prior to any surgery

 

Medium-Chain Acyl-CoA Dehydrogenase Deficiency - How to prevent?

Medium-Chain Acyl-CoA Dehydrogenase Deficiency - Preparing for surgery

Medium-Chain Acyl-CoA Dehydrogenase Deficiency - Post-surgery care

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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