Dolutegravir is an anti-retroviral medication that prevents the replication of viruses. It reduces the amount of viruses (viral load) in the body and keeps it at a low level. It may also be given as post-exposure prophylaxis (PEP), which is a short course of a combination of different anti-retroviral medications to prevent infection after a possible exposure to the virus.
It is always given in combination with other anti-retroviral medications (combination therapy).
Common side effects include:
Inform your doctor if the side effects above become severe and bothersome.
Rare but serious side effects include:
The symptoms of a drug allergy include one or more of the following:
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Inform your healthcare professional if:
Do not take any other medications or herbal products without first consulting your doctor or pharmacist. Some medications may reduce the effectiveness, or increase the toxicity of Dolutegravir. Dolutegravir can also affect how some other medications work.
Speak to your doctor / pharmacist if you are taking any of the following medications:
If you are taking any of these medications, your doctor may need to adjust your drug doses or arrange for closer monitoring.
Missing doses may make Dolutegravir less effective and make the virus resistant to Dolutegravir. This could also make the infection harder to treat. If you forget to take a dose, take the missed dose as soon as you remember. However, if the next dose is due within 4 hours, omit the missed dose and take only at your regular scheduled dose. Do not take two doses to make up for the missed dose.
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