Rufinamide
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Drug Class: Commonly Known As: Category:
Inovelon

Rufinamide - What is it for

​Rufinamide is used to control seizures (fits) associated with Lennox-Gastaut syndrome, which is a severe form of epilepsy where you may have repeated seizures of various types.

Rufinamide - Side Effects, Precautions, and Contraindications

What side effects can Rufinamide cause?

Like all medicines, this medication may cause some possible side effects but not everyone experiences them. Consult your healthcare professional if any of the side effects lasts more than a few days or become severe and bothersome.

The common side effects of Rufinamide include:

  • Dizziness
    • Get up slowly from sitting or lying down position
  • Drowsiness or double vision or blurred vision
    • Avoid driving or engaging in activities that requires concentration
  • Headache
    • Take paracetamol if needed to relieve headache
  • Nausea, vomiting
    • Take the medication with or after food to reduce nausea and vomiting
    • Avoid food that is too rich, spicy or has strong smells
  • Loss of appetite
  • Constipation
    • Drink more water, eat more high-fiber foods and exercise regularly
  • Flu-like symptoms

If the following serious side effects happen, you should consult your healthcare professional immediately:

  • Blistering, peeling, red skin rash due to Stevens-Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN)
    • SJS and TEN are rare and serious skin reactions. Symptoms include face swelling, blisters on skin, skin rashes that spread within hours to days. It usually occurs within the first few months (monitor closely for the first 3 months) of treatment.
    • As SJS and TEN progress rapidly, please consult your healthcare professional if you show the first sign of a rash.
  • Difficulty or pain in urinating, blood in urine
  • Prolonged fever, sore throat and mouth sores
  • Unusual bruises or bleeding
  • Palpitations

In rare cases, this medication may cause the following changes to a person's mental condition, especially in the first few weeks of treatment or during dose changes:

  • Worsening agitation, restlessness, violent behaviour, or
  • New or worsening thoughts of harming yourself or ending your life
  • Other changes in mood or behaviour

Please inform your doctor as soon as possible, or for your family or caregiver to inform your doctor if you are unable to seek treatment on your own.

Do not stop taking this medication on your own without discussing with your doctor.

It is important to note that your doctor has prescribed this medication as he/ she feels you will benefit more from taking this medication over the possible side effects that it may cause, which have a low chance of occurring. Most people take this medication without any such problems.

The symptoms of a drug allergy include one or more of the following:

  • Swollen face / eyes/ lips / tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Rufinamide , what precautions must I follow?

Inform your healthcare professional if you have the following medical conditions before starting on Rufinamide:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are taking any other medications, including supplements, traditional medications and herbal remedies
  • You have congenital short QT syndrome or a family history of such a syndrome (abnormal heart rhythm)
  • You have any liver problems

For women: Tell your doctor if you are pregnant and/or breastfeeding, your doctor would have discussed the potential benefits and side effects with continuing/starting this medication.

Consult your healthcare professional immediately if your seizures get worse or become different after you start on this medication.

What food or medicine must I avoid when I take Rufinamide ?

  • ​Avoid drinking alcohol while taking this medication as it can cause excessive drowsiness.
  • Some medications may affect how the medication works or be affected by the medication. Inform your doctor/pharmacist if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

Rufinamide - Dosage and How to Use

How should Rufinamide be used?

  • Follow the instructions on your medication label and take the medication as prescribed by your doctor.
  • Take this medication with or after food.
  • Swallow the tablets with a glass of water. If you are unable to swallow the tablet, you may crush it and add it to a small amount of food (such as yoghurt, ice-cream, syrup) or water.
  • You may not experience any benefits immediately after starting the medication as it may take up to a few weeks before this medication can exert its full effects. You should continue to take your medication regularly as instructed by your doctor even if you feel well. Stopping your medication without informing your healthcare professional may cause your condition to worsen quickly.
  • Do not stop taking or adjust the dose of this medication without consulting your healthcare professional.

What should I do if I miss a dose?

​If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

Rufinamide - Handling

How should I handle Rufinamide safely?

Rufinamide - Storage

How should I store Rufinamide ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Rufinamide safely?

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Rufinamide - Additional Information

  • Updated on 5/17/2022 12:00:00 AM
  • Article contributed by Pharmacy Department KK Women's and Children's Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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