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Drug Class: Commonly Known As: Category:
Angiotensin Receptor-Neprilysin Inhibitors (ARNi) Entresto Adult

Sacubitril/Valsartan - Side Effects, Precautions, and Contraindications

What side effects can Sacubitril/Valsartan cause?

  • Dizziness
  • Angioedema (swelling of face, lips, tongue or throat that results in trouble in breathing)
  • Your doctor may need to monitor you for electrolytes imbalances when you are on this medication

Before taking Sacubitril/Valsartan, what precautions must I follow?

  • Do not take sacubitril/valsartan for at least 36 hours before or after you take an ACE inhibitor medicine
  • Inform your doctor if you are taking these medications (potassium supplements, nonsteroidal anti-inflammatory drugs NSAIDs, lithium or other high blood pressure medications such as ACE inhibitor, ARB, aliskiren)
  • Inform your doctor if you have any kidney or liver problems.
  • Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding.

You should not take this medicine if you:

  • have allergy to any sacubitril, valsartan or any component of Entresto
  • have a history of angioedema related to previous ACE inhibitor or ARB therapy
  • are taking ACE inhibitors
  • are diabetic and taking aliskiren
  • are pregnant
  • are breastfeeding
  • have poor kidney function

What food or medicine must I avoid when I take Sacubitril/Valsartan?

Sacubitril/Valsartan - Additional Information

  • Updated on Tuesday, September 6, 2016
  • Article contributed by Department of Pharmacy National Heart Centre Singapore

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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