• Dizziness
• Angioedema (swelling of face, lips, tongue or throat that results in trouble in breathing)
• Your doctor may need to monitor you for electrolytes imbalances when you are on this medication

• Do not take sacubitril/valsartan for at least 36 hours before or after you take an ACE inhibitor medicine
• Inform your doctor if you are taking these medications (potassium supplements, nonsteroidal anti-inflammatory drugs NSAIDs, lithium or other high blood pressure medications such as ACE inhibitor, ARB, aliskiren)
• Inform your doctor if you have any kidney or liver problems.
• Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding.

You should not take this medicine if you:

• have allergy to any sacubitril, valsartan or any component of Entresto
• have a history of angioedema related to previous ACE inhibitor or ARB therapy
• are taking ACE inhibitors
• are diabetic and taking aliskiren
• are pregnant
• are breastfeeding
• have poor kidney function