Sulphasalazine belongs to a group of medicines called aminosalicylate which is used to reduce pain and swelling in joint conditions e.g. rheumatoid arthritis.
It is one of the disease-modifying-anti-rheumatic drugs (DMARDs) which can modify the progress of clinical disease by reducing permanent damage to joints caused by continuing inflammation.
It may be combined with other DMARDs or biologic agents to control the disease.
In general, most patients can take sulfasalazine with few side effects.
The tablets may cause your urine to turn an orange colour and if you are wearing contact lenses, it may get stained. DO NOT be alarmed by these signs.
Common side effects
Rare side effects
Come back to the hospital for regular blood test as instructed by your doctor.
Because adverse effects can happen at any time during the course of treatment and some side effects may not cause symptoms, it is really important that you have your regular blood test.
Avoid prolonged exposure to sun and use sunscreen as this medicine may cause the skin to be more sensitive to sunlight.
Sulphasalazine can lower sperm counts and motility may be lowered. These go back to normal within 2 months after the drug is stopped. Do inform your doctor or pharmacist if intending to start a family.
It is given orally, after food to prevent stomach upset, usually once, twice or even up to three times a day.
A typical dose will range from 500mg to 3g a day, varying for each person depending upon factors such as activities of your disease and your response to the treatment.
Sulphasalazine tablets should be swallowed whole, with a glass of water. The tablets should not be crushed or chewed.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
DO NOT double the dose to make up for the missed dose.
Sulphasalazine should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Come back to the hospital if you have:
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