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Trifluridine/Tipiracil

Drug Class: Commonly Known As: Category:
Antineoplastic Thymidine-based Nucleoside Analog + Thymidine Phosphorylase Inhibitor Lonsurf®

Trifluridine/Tipiracil - What is it for

​Lonsurf® (trifluridine/tipiracil) is used to treat colorectal cancer that has spread to other parts of the body. It is normally used in patients who have either tried or cannot use other medications for their cancer.

Trifluridine/Tipiracil - Side Effects, Precautions, and Contraindications

What side effects can Trifluridine/Tipiracil cause?

  • ​Nausea and vomiting
    • Take small, frequent meals throughout the day.
    • Take the medications for nausea or vomiting as instructed by your doctor if any.
  • Diarrhea
    • Drink plenty of clear fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Slight ache or tenderness around the stomach area
    • Avoid food that causes bloating or gas production in the stomach.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Decreased white blood cells, red blood cells and platelets
    • This may put you at higher risk of infections, bleeding or bruising and feeling tired.
    • To reduce your risk of infection:
      • Avoid crowds and people who are sick. Wear a face mask when you are going out.
      • Wash your hands after using the toilet and before handling food.
      • Eat food that is fresh and completely cooked, and avoid raw or half-cooked food.
    • To reduce your risk of bleeding problems:
      • Be careful when using sharp objects such as knives.
      • Try not to bruise, cut or knock yourself.
      • Brush your teeth gently as your gums may bleed more easily.
      • Apply direct pressure to any cuts or wounds to help stop bleeding.

Please see your healthcare professional immediately if any of the following occur:

  • Signs of infection - fever of 38° C and above, chills, cough, body aches
  • Unhealthy pale skin colour, light-headedness, increasing tiredness or weakness
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Trifluridine/Tipiracil, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy
    • You should use effective birth control during and for 6 months after stopping treatment.
  • You are breastfeeding
    • Do not breastfeed during and for 1 day after the last dose of treatment.
  • You are taking or intending to take any other medication, supplements, traditional medications or herbal remedies

What food or medicine must I avoid when I take Trifluridine/Tipiracil?

Trifluridine/Tipiracil - Dosage and How to Use

How should Trifluridine/Tipiracil be used?

  • ​Take Lonsurf® two times a day from Day 1 to 5 and Day 8 to 12 of a 28 day-cycle.
  • Take it within 1 hour after a meal.
  • Do not break, chew or crush the tablet. Swallow the tablet whole.
    • Inform your doctor or pharmacist if you have difficulty swallowing.

What should I do if I miss a dose?

​If you forget to take a dose, skip the missed dose and take your next dose at the usual time. Do not take additional doses to make up for the missed dose.

What should I do if I overdose?

Trifluridine/Tipiracil - Handling

How should I handle Trifluridine/Tipiracil safely?

Trifluridine/Tipiracil - Storage

How should I store Trifluridine/Tipiracil?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Trifluridine/Tipiracil safely?

​Pack Lonsurf® into a bag and bring it back to the pharmacy where you received it from.

Trifluridine/Tipiracil - Additional Information

​You may refer to the following website if you need more information: https://www.macmillan.org.uk/

  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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