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Tegafur/Gimeracil/Oteracil (TS-1®)

Drug Class: Commonly Known As: Category:
Antimetabolite TS-1® Cancer-related

Tegafur/Gimeracil/Oteracil (TS-1®) - What is it for

​TS-1® is a combination oral chemotherapy used to treat certain types of advanced cancer e.g. gastric, pancreatic, head and neck.   

Tegafur/Gimeracil/Oteracil (TS-1®) - Side Effects, Precautions, and Contraindications

What side effects can Tegafur/Gimeracil/Oteracil (TS-1®) cause?

  • Nausea and vomiting
  • Diarrhea
  • Tiredness and lack of energy
  • Decrease white and red blood cells, platelets
    To minimize infection risk, ensure personal hygiene and take adequate precautions e.g. avoiding crowded areas. 

Inform your doctor if any of the following occurs:

  • Fever of 38°C or higher, sores in the mouth and throat 
  • Sudden onset of cough or shortness of breath
  • Chest pain or irregular heartbeat
  • Unusual bleeding, bruising or black stools
  • Severe diarrhea uncontrolled by anti-diarrheal medication e.g. more than 4 times/day
  • Yellowing of the eyes or skin, dark tea-coloured urine and severe abdominal pain
  • Skin rash or itch

Before taking Tegafur/Gimeracil/Oteracil (TS-1®), what precautions must I follow?

  • Use effective birth control during treatment and for 6 months after stopping TS-1®. Inform your doctor if you or your partner suspect or plan for pregnancy.
  • Inform your doctor or pharmacist if you:
    • Are taking other medication or supplements e.g. warfarin, phenytoin.
    • Have any other medical conditions e.g. heart problems.

What food or medicine must I avoid when I take Tegafur/Gimeracil/Oteracil (TS-1®)?

Tegafur/Gimeracil/Oteracil (TS-1®) - Dosage and How to Use

How should Tegafur/Gimeracil/Oteracil (TS-1®) be used?

It is a capsule taken by mouth, twice daily after breakfast and dinner.
The dose given is based on your body weight and height. Take the exact number of capsules and follow the dosing schedule instructed by your doctor.

What should I do if I miss a dose?

​If you miss a dose of TS-1®, take it as soon as you remember. However if it is too near to your next dose, skip the missed dose and go back to your usual dosing time. Do not double the dose.

What should I do if I overdose?

​If you overdose on this medication, inform your doctor immediately.

Tegafur/Gimeracil/Oteracil (TS-1®) - Handling and Storage

How should I handle Tegafur/Gimeracil/Oteracil (TS-1®) safely?

​Do not crush, chew or open the capsules.

How should I store Tegafur/Gimeracil/Oteracil (TS-1®)?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Tegafur/Gimeracil/Oteracil (TS-1®) safely?

Tegafur/Gimeracil/Oteracil (TS-1®) - Additional Information

  • Updated on Monday, February 25, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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