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Drug Class: Commonly Known As: Category:
Soluble Guanylate Cyclase (sGC) Stimulator Adempas

Riociguat - Side Effects, Precautions, and Contraindications

What side effects can Riociguat cause?

  • Riociguat may cause the following side effects:
  • giddiness, low blood pressure, limb swelling,headache, stomach discomfort or nausea. These effects are minimized by starting with a lower dose. If they do not improve or go away with time, consult the Pulmonary Hypertension Team for advice.
  • To reduce giddiness when changing position, rise slowly from a sitting or lying position.
  • A potential but rare side effect is having abnormal bleeding, for example coughing up small amounts of blood, having nose bleeds or unexplained bruising on the skin. If this occurs, call the Pulmonary Hypertension team for advice.

Before taking Riociguat, what precautions must I follow?

As this medication may cause birth defects, female patients of childbearing age should take precautions by using at least 2 reliable methods of contraception to avoid pregnancy. If you suspect you may be pregnant, inform your Cardiologist as soon as possible.

What food or medicine must I avoid when I take Riociguat?

  • Inform your Cardiologist, Nurse and/or Pharmacist if you are taking any other over-the- counter (OTC) medications, health/herbal supplements or traditional medications. The Pulmonary Hypertension Team will check to ensure that the combination of medications you are taking is safe.
  • If you are taking Riociguat, you should avoid certain kinds of medications. Some examples are: Nitrates (for relieving chest pain), Phosphodiesterase-5 inhibitors (for erectile dysfunction) or Alpha-blockers (for treatment of high blood pressure or urinary conditions like benign prostate hyperplasia).
  • Take Riociguat at least 1 hour apart from gastric-acid reducing agents like antacids.
  • Avoid grapefruit juice while taking Riociguat.

Riociguat - Additional Information

  • Updated on
  • Article contributed by Department of Pharmacy National Heart Centre Singapore

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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